… We next examined whether selective activation of somatodendritic DREADDs impacts cocaine
potency at distal DATs in the NAc. We implanted bilateral cannulae targeted to the VTA of …

… levels such as the type achieved by allosteric targeting of dopamine transporter activity. …
effects on behavior. The normalization of dopamine uptake and extracellular dopamine levels …

… 2) reduced effects of cocaine on extracellular DA … attenuating subjective or reinforcing
effects of cocaine 59 , it is possible that phendimetrazine may be successful as part of a dual-target …

… -dependent monoamine transporter 23 , is a clinical target for … addictive effects of psychoactive
substances such as cocaine and … extracellular dopamine leading to attenuated dopamine-…

… large number of potential off-target sites. Here, we … attenuate the action of psychostimulants
like cocaine and AMPH, reinforcing our decision to examine potential in vivo consequences …

… extracellular dopamine level resulting in euphoria. Although … First, we gave the rats had
cannula implanted targeting the … whether KM822 will attenuate cocaine-induced hyperlocomotion …

… DAT is a major target for drugs of abuse including cocaine, … inhibitors like cocaine disrupt
this extracellular gate thereby … were able to attenuate the inhibitory effect of cocaine and Tat …

… altered dopamine transport kinetics and increased cocaine-… TM4-9 hub a new target for
pharmacological modulation of DAT … reuptake of dopamine from the extracellular space. The …

… Cocaine is a monoamine transport blocker, elevating extracellular concentrations of brain
dopamine … how long-term cocaine exposure on DAT function can be used as a target for novel …

… , dopamine can have completely opposing effects on target … reuptake of extracellular
dopamine into the intracellular space. … -mediated DAT internalization is blocked by cocaine which …